A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/14 (2006.01) A01N 1/02 (2006.01) A61K 38/18 (2006.01) A61K 47/02 (2006.01) A61K 47/08 (2006.01) A61K 47/26 (2006.01) A61K 47/42 (2006.01) A61L 15/40 (2006.01) A61L 17/00 (2006.01) A61L 27/38 (2006.01) A61L 31/14 (2006.01) A61P 7/04 (2006.01) A61P 17/02 (2006.01) A61L 25/00 (1990.01) C12N 5/08 (2006.01)
Patent
CA 2136848
Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and re-lease their granular contents: Pharmaceutical formulations containing the same are also disclosed. The platelets are preferably fixed by means of a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by means of a permanganate fixate. The platelets are preferably dried by lyophilization.
Bode Arthur P.
Read Marjorie S.
Reddick Robert L.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
East Carolina University
University Of North Carolina At Chapel Hill
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