Method for producing of a bio-artificial transplant

A - Human Necessities – 61 – L

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A61L 27/38 (2006.01) A61L 27/50 (2006.01)

Patent

CA 2410622

The invention relates to a method for producing a bio-artificial transplant from biological tissue provided for transplantation, which has cells that are compatible with the recipient applied thereto. According to the invention, a controlled tissue generation is carried out in-vitro, during which selected cells that are capable of remodelling the carrier structures are added to native tissue that is maintained in a culture and the culture is continued until a new tissue which has been substantially transformed is obtained, said tissue containing the added recipient-compatible cells.

L'invention concerne un procédé de fabrication d'un transplant bio-artificiel à partir d'un tissu biologique prévu pour la transplantation et de cellules compatibles avec le receveur introduites dans ce tissu. Selon l'invention, une régénération de tissu contrôlée est réalisée in vitro, selon laquelle des cellules sélectionnées, aptes au remodelage des structures porteuses, sont introduites dans un tissu natif en culture et la culture est poursuivie jusqu'à l'obtention d'un nouveau tissu sensiblement transformé, contenant les cellules introduites et compatibles avec le receveur.

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