Cyclic protein free from cysteines

Details Cyclic protein free from cysteines Cyclic protein free from cysteines

C - Chemistry, Metallurgy

07

K

C07K 14/525 (2006.01) A61K 38/19 (2006.01)

Patent

CA 2708134

A protein selected from the amino acid sequence of the region valine Val(91) to glycine Gly(121) of the mature human tumour necrosis factor, or a portion thereof, with the proviso that the protein comprises at least the amino acid sequence of the region lysine Lys(98) to glutamic acid Glu(116), with the cysteine Cys(101) being replaced by a glycine and an amide bond being formed between the amino group of the side chain of the lysine Lys(98) and the carboxyl group of the side chain of the glutamic acid Glu(116), which activates epithelial ion channels and improves the lung function and which can be used for the manufacture of medicaments for the treatment of diseases associated with the lung function, such as oedemas.

L'invention concerne une protéine choisie dans la séquence d'acides aminés de la région valine Val(91) à glycine Gly(121) du facteur de nécrose tumorale humain mûr, ou dans une partie de celle-ci, avec la condition que la protéine contienne au moins la séquence d'acides aminés de la région lysine Lys(98) à acide glutaminique Glu(116), la cystéine Cys(101) étant remplacée par une glycine. Une liaison amide est créée entre le groupe amino de la chaîne latérale de la lysine Lys(98) et le groupe carboxyle de la chaîne latérale de l'acide glutaminique Glu(116), ladite liaison activant des canaux ioniques épithéliaux et améliorant la fonction pulmonaire. La protéine selon l'invention peut être employée pour la fabrication de médicaments pour le traitement de maladies associées à la fonction pulmonaire, telles que des oedèmes.

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