Heparan sulfate glycosaminoglycan lyase and uses thereof

Details Heparan sulfate glycosaminoglycan lyase and uses thereof Heparan sulfate glycosaminoglycan lyase and uses thereof

A - Human Necessities

61

K

A61K 38/47 (2006.01) C07H 21/04 (2006.01) C08B 37/10 (2006.01) C12N 9/88 (2006.01) C12P 19/28 (2006.01)

Patent

CA 2628216

The invention provides recombinant B. thetaiotaomicron GAG lyase polypeptides. The invention also provides nucleic acid molecules encoding such polypeptides, recombinant expression vectors containing B. thetaiotaomicron GAG lyase nucleic acid molecules, and host cells into which the expression vectors have been introduced. Characterization, diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

L'invention concerne des polypeptides recombinants de lyase GAG de B. thetaiotaomicron. Elle concerne également des molécules d'acide nucléique codant lesdits polypeptides, les vecteurs d'expression recombinants contenant des molécules d'acide nucléique de lyase GAG de B. thetaiotaomicron, et les cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits. L'invention porte également sur les procédés thérapeutiques et les procédés de caractérisation et de diagnostic utilisant les compositions de l~invention.

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