Solid salt forms of a pyrrole substituted 2-indolinone

Details Solid salt forms of a pyrrole substituted 2-indolinone Solid salt forms of a pyrrole substituted 2-indolinone

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/404 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2621569

The present invention relates to solid salt forms of the 3-pyrrole substituted 2-indolinone compound 5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]- 2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pirrolidin-1-yl-ethyl)-amide. It also relates to polymorphs of the phosphate salt of the amide. The invention further relates to the use of the salts and polymorphs in the treatment of protein kinase related disorders.

L'invention porte sur composés de sels solides de 2-indolinone à substitution 3 du (2-pirrolidin-1-yl-éthyl)-amide de l'acide 5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidèneméthyl]-2,4-diméthyl-1H-pyrrole-3-carboxylique, et sur des forme polymorphes du sel de phosphate de l'amide. L'invention porte également sur l'utilisation de ces sels et polymorphes pour le traitement de troubles liés à la protéine kinase.

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