C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01) A61K 31/404 (2006.01) A61P 43/00 (2006.01) C07D 403/14 (2006.01) C07F 9/572 (2006.01) C07F 9/6558 (2006.01)
Patent
CA 2408709
The present invention is directed to Mannich base prodrugs of certain 3- (pyrrol-2-ylmethylidene)-2-indolinone derivatives of formula (I): that modulate the activity of protein kinases ("PKs"). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
L'invention concerne des promédicaments à base de Mannich de certains dérivés de 3-(pyrrol-2-ylméthylidène)-2-indolinone qui modulent l'activité de protéines kinases ("PK"). L'invention concerne également des compositions pharmaceutiques comprenant ces composés, des méthodes de traitement de maladies associées à une activité PK anormale au moyen des compositions pharmaceutiques comprenant ces composés ainsi que des méthodes de préparation de ces compositions pharmaceutiques.
Gao Ping
Moon Malcolm Wilson
Morozowich Walter
Tang Peng Cho
Osler Hoskin & Harcourt Llp
Pharmacia & Upjohn Company
Sugen Inc.
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