New aryl-and heteroarylethenylene derivatives and process...

Details New aryl-and heteroarylethenylene derivatives and process... New aryl-and heteroarylethenylene derivatives and process...

C - Chemistry, Metallurgy

07

C

C07C 255/32 (2006.01) A61K 31/00 (2006.01) C07C 59/42 (2006.01) C07C 59/52 (2006.01) C07C 59/54 (2006.01) C07C 235/34 (2006.01) C07C 255/36 (2006.01) C07C 255/41 (2006.01) C07C 327/44 (2006.01) C07D 209/34 (2006.01) C07D 213/02 (2006.01) C07D 215/02 (2006.01) C07D 215/14 (2006.01) C07D 215/20 (2006.01) C07D 215/227 (2006.01) C07D 215/233 (2006.01) C07D 215/26 (2006.01) C07D 277/36 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2053253

Aryl- and heteroarylethenylene derivatives of formula (I) wherein Y is a mono- or bicyclic ring system chosen from (A), (B), (C), (D), (E), (F) and (G); R is a group of formula (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j) in which R3 is -OH or -NH2 and Ph means phenyl; R1 is hydrogen, C1-C6 alkyl or C2-C6 alkanoyl; R2 is hydrogen, halogen, cyano or C1-C6 alkyl; n is zero or an integer of 1 to 3; n is zero or an integer of 1 to 3 when Y is a ring system (A); it is zero, 1 or 2 when Y is a ring system (B), (E), (F) or (G); or it is zero or 1 when Y is a ring system (C) or (D); and the pharmaceutically acceptable salts thereof; and wherein each of the substituents R, OR1 and R2 may be independently on either of the aryl or heteroaryl moieties of the bicyclic ring system (A), (E), (F) and (G), whereas only the benzene moiety may be substituted in the bicyclic ring system (B), are useful as tyrosine kinase activity inhibitors.

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