Transdermal patch for external use comprising fentanyl

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/4468 (2006.01) A61K 9/70 (2006.01) A61K 47/06 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/32 (2006.01) A61K 47/46 (2006.01)

Patent

CA 2502220

A transdermal patch for external use having a backing layer and a pressure-sensitive adhesive layer formed on one surface of the backing layer, which contains polyisobutylene, a mineral oil and fentanyl employed as the active ingredient in the pressure-sensitive adhesive layer and in which the contents of polyisobutylene and fentanyl in the pressure-sensitive adhesive layer respectively range from 75.2 to 94.2% by mass and 1 to 6% by mass while the content of the mineral oil is from 0.25 to 0.05 parts by mass based on polyisobutylene. This patch can be easily produced, has a long-lasting effect and is excellent in adhesion to the skin and tolerability against movement to the body parts.

Cette invention concerne un timbre transdermique à usage externe comportant un substrat dont une des faces est recouverte d'une couche autoadhésive renfermant du polyisobutylène, une huile minérale et du fentanyle comme principe actif, couche dans laquelle les teneurs en polyisobutylène et en fentanyle sont comprises entre 75,2 % et 94,2 %, et 1 et 6 %, respectivement, par masse pour une teneur en huile minérale comprise entre 0,35 et 0,05 partie en masse par rapport au polyisobutylène. Ce timbre facile à produire, à action prolongée présente un pouvoir adhésif sur la peau et des propriétés pour la suite du processus remarquables.

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