Methods of binding of cross-beta structures by chaperones

Details Methods of binding of cross-beta structures by chaperones Methods of binding of cross-beta structures by chaperones

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2645930

The invention relates to the field of biochemistry, biophysical chemistry, molecular biology, structural biology, immunology, cellular biology and medicine. More in particular, the invention relates to the capability (or property) of chaperones to bind a crossbeta structure. Even more in particular, the invention relates to extracellular chaperones such as BiP, haptoglobin, hsp72 or clusterin. The present invention provides the insight that a chaperone molecule and more in specific an extra-cellular chaperone molecule (such as for example BiP, clusterin, hsp72 or haptoglobin) is capable of interacting with a crossbeta structure and/or a molecule comprising a crossbeta structure and/or a molecule comprising a crossbeta structure precursor. Based on this insight, the present inventors have developed multiple methods and means.

L'invention concerne le domaine de la biochimie, de la chimie biophysique, de la biologie moléculaire, de la biologie structurelle, de l'immunologie, de la biologie cellulaire et de la médecine. Plus particulièrement, l'invention concerne la capacité (ou la propriété) de molécules chaperonnes de se lier à une structure bêta croisée. Encore plus particulièrement, l'invention concerne des molécules chaperonnes extracellulaires telles que BiP, l'haptoglobine, hsp72 ou la clustérine. La présente invention ouvre de nouvelles perspectives sur la capacité d'une molécule chaperonne, et plus spécifiquement une molécule chaperonne extra-cellulaire (telle que par exemple BiP, la clustérine, hsp72 ou l'haptoglobine), d'interagir avec une structure bêta croisée et/ou une molécule contenant une structure bêta croisée et/ou une molécule contenant un précurseur de structure bêta croisée. Sur la base de cette perspective, les présents inventeurs ont développé de multiples procédés et moyens.

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