Promoter for smooth muscle cell expression

Details Promoter for smooth muscle cell expression Promoter for smooth muscle cell expression

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 31/70 (2006.01) A61K 35/34 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2267067

Disclosed is a smooth muscle cell specific promoter, the SM22.alpha. gene promoter as well as the murine cDNA and genomic SM22.alpha. nucleic acid sequences. Also disclosed are methods of preventing restenosis following balloon angioplasty and methods of treating asthma based on inhibition of smooth muscle cell proliferation by expressing cell cycle control genes, or contraction inhibiting peptides in smooth muscle cells, under the control of the SM22.alpha. promoter.

L'invention concerne un promoteur spécifique de la cellule musculaire lisse, le promoteur du gène SM22.alpha. ainsi que des séquences nucléotidiques d'ADNc murin et de SM22.alpha. génomique. Elle porte également sur des méthodes de prophylaxie de la resténose faisant suite à une angioplastie transluminale percutanée ainsi que sur des méthodes de thérapie de l'asthme se fondant sur l'inhibition de la prolifération de la cellule musculaire lisse au moyen de l'expression de gènes de régulation du cycle cellulaire ou utilisant des peptides inhibant les contractions des cellules musculaires lisses, sous l'égide du promoteur de SM22.alpha..

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