Methods of using anti-thymocyte globulin and related agents

Details Methods of using anti-thymocyte globulin and related agents Methods of using anti-thymocyte globulin and related agents

C - Chemistry, Metallurgy

12

N

C12N 5/0783 (2010.01) C12N 5/078 (2010.01) A61K 35/14 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2653848

Uses for ant i- thymocyte globulin (ATG, e.g., Thymoglobulin®) and related compositions are described. In one aspect, ATG and, optionally, TGF-beta are used for in vitro generation of regulatory T cells, which are useful for cell therapy of immune-mediated conditions. In another aspect, ATG is directly administered to a subject at a low dose (e.g., less than 1 mg/kg per day) to treat an immune-mediated condition. The immune-mediated conditions include, for example, transplant rejection, graft-versus-host disease, and autoimmune diseases.

La présente invention concerne de nouvelles utilisations de la globuline anti-thymocyte (ATG, par exemple, Thymoglobulin®) et des compositions associées. Dans un aspect, l'ATG et, éventuellement, le facteur de croissance transformant .beta. (TGF-.beta.) sont utilisés pour la génération in vitro de lymphocytes T régulateurs, qui se révèlent utiles en thérapie cellulaire de pathologies immunitaires. Dans un autre aspect, l'ATG est administrée directement à un sujet, à faible dose (par exemple, moins de 1 mg/kg par jour), en vue de traiter une pathologie immunitaire. Lesdites pathologies immunitaires incluent notamment le rejet de greffe, la maladie du greffon contre l'hôte et des maladies autoimmunes.

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