Sesterterpene derivatives exhibiting antifungal activities

Details Sesterterpene derivatives exhibiting antifungal activities Sesterterpene derivatives exhibiting antifungal activities

C - Chemistry, Metallurgy

07

D

C07D 311/94 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2339291

Compounds represented by general formula (I); and pharmaceutically acceptable salts or esters thereof, (wherein Y1 is oxygen, NH, O-CO, O-SO2, O-CO-NH, O-CS- NH, NH-CO, NH-SO2, NH-CO-NH or NH-CS-NH; and R1 is alkyl, alkenyl, alkynyl, aryl, aralkyl, arylalkenyl, arylalkynyl, cycloalkyl, cycloalkylalkyl, alkylcarbonyl, alkoxycarbonyl, arylcarbonyl or a heterocyclic group, provided these groups may be optionally substituted). The above compounds, salts and esters exert excellent antifungal effects on fungi against which the existing antifungal agents are not sufficiently efficacious, thus being useful as antifungal agents.

L'invention concerne des composés représentés par la formule générale (I), ainsi que des sels ou esters de ceux-ci, acceptables sur le plan pharmacologique. Dans cette formule, Y?1¿ représente oxygène, NH, O-CO, O-SO¿2?, O-CO-NH, O-CS-NH, NH-CO, NH-SO¿2?, NH-CO-NH ou NH-CS-NH, et R?1¿ représente alkyle, alcényle, alcynyle, aryle, aralkyle, arylalcényle, arylalcynyle, cycloalkyle, cycloalkylalkyle, alkylcarbonyle, alcoxycarbonyle, arylcarbonyle ou un groupe hétérocyclique, à condition que ces groupes puissent être éventuellement substitués. Les composés ci-dessus, et leurs sels et esters, exercent d'excellents effets antifongiques sur des champignons contre lesquels les agents antifongiques existants ne sont pas suffisamment efficaces, et ils constituent donc des agents antifongiques utiles.

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