Improved glucocorticoid therapy

Details Improved glucocorticoid therapy Improved glucocorticoid therapy

A - Human Necessities

61

K

A61K 31/573 (2006.01) A61P 5/44 (2006.01)

Patent

CA 2757858

The present invention relates to improved glucocorticoid therapy and to treatment or prevention of a number of disorders that are due to a diminished or disrupted endogenous glucocorticoid secretory pattern. The invention is based on the findings that producing a specific serum Cortisol time profile that mimics the circadian rhythm of Cortisol of a healthy subject in a subject suffering from a diminished or disrupted glucocorticoid secretory pattern gives benefits with respect to reduction of side-effects.

L'invention porte sur une amélioration de la thérapie par les glucocorticoïdes et sur le traitement ou la prévention de différents troubles dus à une diminution ou à une perturbation du mécanisme sécrétoire endogène des glucocorticoïdes. L'invention se fonde sur une découverte selon laquelle l'élaboration, chez un patient présentant un mécanisme sécrétoire endogène des glucocorticoïdes diminué ou réduit, d'un profil temporel spécifique du cortisol sérique calquant celui du rythme circadien du cortisol chez un sujet sain. L'invention s'avère bénéfique du point de vue de la réduction des effets secondaires.

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