Gene that imparts selective proliferative activity

Details Gene that imparts selective proliferative activity Gene that imparts selective proliferative activity

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 14/715 (2006.01) C07K 14/72 (2006.01) C07K 19/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12N 15/16 (2006.01) C12N 15/19 (2006.01)

Patent

CA 2248878

It has become possible to amplify cells selectively by introducing thereinto a gene coding for a fusion protein containing (a) a region to which a ligand binds, (b) a region which causes association when a ligand binds to the region (a) and (c) a region which imparts the cells a proliferative activity when the association occurs, and giving the cells ligand stimulation.

On peut amplifier des cellules d'une manière sélective, en y introduisant un gène codant pour une protéine de fusion contenant (a) une région à laquelle se fixe un ligand, (b) une région qui provoque une association quand un ligand se fixe à la région (a), et une région (c) qui provoque une prolifération cellulaire quand l'association se produit et stimule le ligand cellulaire.

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