C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 38/17 (2006.01) C07K 14/435 (2006.01) C07K 16/42 (2006.01) G01N 33/564 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2296842
The invention provides monoclonal and polyclonal antibodies recognising molecules on secretory cells of various tissue targets of autoimmune disease allowing a unifying method of preventing and treating autoimmune diseases and other conditions where hormonal dysregulation, hyperinsulinaemia and insulin resistance are involved. It also provides a method for detecting similar antibodies in human sera or other body fluids which can be used in the development of diagnostic kits. Treatment methods arising from this invention comprise the administration of preparations of the antibodies, their target molecules and vectors containing coding sequences of the antibodies and their target molecules.
L'invention concerne des anticorps monoclonaux et polyclonaux reconnaissant des molécules situées sur les cellules sécrétrices de plusieurs tissus qui sont la cible de maladies auto-immunes, ce qui permet d'obtenir un procédé prophylactique et thérapeutique contre les maladies auto-immunes et autres états associés à un dérèglement hormonal, à une hyperinsulinémie et à une insulinorésistance. L'invention concerne également une procédé de détection d'anticorps similaires dans le sérum humain ou autres fluides corporels, pouvant être utilisés pour la mise au point de kits de diagnostic. Les méthodes de traitement selon l'invention consistent à administrer des préparations d'anticorps et de leurs molécules cibles ainsi que des vecteurs contenant des séquences codantes des anticorps et leurs molécules cibles.
Matossian-Rogers Arpi
Sim & Mcburney
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