C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/075 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2295105
The invention discloses novel means and methods for the generation of adenovirus vector. One method of the invention entails a method for generating an adenovirus vector comprising welding together two nucleic acid molecules whereby said molecules comprise partially overlapping sequences capable of combining with each other allowing the generation of a physically linked nucleic acid comprising at least two functional adenovirus inverted terminal repeats, a functional encapsulation signal and a nucleic acid of interest or functional parts, derivatives and/or analogues thereof. The invention further discloses nucleic acid molecules for generation adenovirus vectors.
L'invention concerne de nouveaux moyens et procédés de production d'un vecteur d'adénovirus, dont un procédé consiste à souder ensemble deux molécules d'acide nucléique. Ces molécules comprennent des séquences partiellement superposées capables de se combiner pour générer un acide nucléique physiquement couplé comprenant au moins deux séquences fonctionnelles d'adénovirus de répétition terminale inverse, un signal d'encapsulation fonctionnel et un acide nucléique ayant des parties d'intérêt ou fonctionnelles, des dérivés et/ou analogues desdits éléments. L'invention concerne en outre des molécules d'acide nucléique pouvant générer des vecteurs d'adénovirus.
Bout Abraham
Vogels Ronald
Borden Ladner Gervais Llp
Crucell Holland B.v.
Introgene B.v.
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