Cytokine-, stress-, and oncoprotein-activated human protein...

Details Cytokine-, stress-, and oncoprotein-activated human protein... Cytokine-, stress-, and oncoprotein-activated human protein...

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A61K 38/43 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C12N 9/12 (2006.01) C12Q 1/00 (2006.01) C12Q 1/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2295876

Disclosed are human mitogen-activated (MAP) kinase kinase isoforms (MKKs). MKKs mediate unique signal transduction pathways that activate human MAP kinases p38 and JNK, which result in activation of other factors, including activating transcription factor-2 (ATF2) and c-Jun. The pathways are activated by a number of factors, including cytokines and environmental stress. Methods are provided for identifying reagents that modulate MKK function or activity and for the use of such reagents in the treatment of MKK-mediated disorders.

L'invention concerne des isoformes (MKK) des kinases de kinase activée par mitogène humain (MAP). Les MKK induisent des voies uniques de transduction du signal activant les kinases MAP humaines p38 et JNK, ce qui provoque l'activation d'autres facteurs, notamment l'activation du facteur-2 de transcription (ATF2) et du c-Jun. Les voies sont activées par un certain nombre de facteurs, parmi lesquels des cytokines et le stress environnemental. L'invention concerne des procédés d'identification de réactifs modulant la fonction ou l'activité MKK, ainsi que des méthodes d'utilisation de tels réactifs pour le traitement de troubles induits par MKK.

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