A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 31/00 (2006.01)
Patent
CA 2523475
A method of preparing a pharmaceutical formulation comprises providing a solution comprising a first solvent, a second solvent, an active agent, and an excipient. The second solvent is less polar than the first solvent and the excipient is more soluble in water than the active agent. The first and second solvents are removed from the solution to produce particles comprising the active agent and the excipient. In one version, the excipient comprises an amino acid and/or a phospholipid. A pharmaceutical formulation made by a version of the invention comprises particles comprising an active agent and an excipient which at least partially encapsulates the active agent, wherein the excipient is more soluble in water than the active agent. An alcoholic aqueous solution containing a drug, which is preferably water insoluble, an amino acid and/or a phospholipid is spray dried.
L'invention concerne un procédé de préparation d'un produit pharmaceutique formulé, qui consiste à fournir une solution comprenant un premier solvant, un second solvant, un principe actif et un excipient. Le second solvant est moins polaire que le premier et l'excipient est plus soluble dans l'eau que le principe actif. Les premier et second solvants sont supprimés de la solution en vue de la production de particules comprenant le principe actif et l'excipient. Dans une version, l'excipient comprend un acide aminé et/ou un phospholipide. Un produit pharmaceutique formulé fabriqué selon une version de l'invention, comprend des particules contenant un principe actif et un excipient qui encapsule au moins partiellement le principe actif, l'excipient étant plus soluble dans l'eau que le principe actif.
Lechuga-Ballesteros David
Miller Danforth P.
Vehring Reinhard
Gowling Lafleur Henderson Llp
Nektar Therapeutics
Novartis Ag
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