C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/40 (2006.01) C12N 5/18 (2006.01) C12N 9/48 (2006.01) C12Q 1/37 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2250141
The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, it relates to three monoclonal antibodies reactive with PSMA expressed on the cell surface and in sera of prostate cancer patients. Additionally, the present invention relates to a novel protein variant (PSM') of PSMA detected by an antibody of the invention. The hydrolase activity of PSMA and PSM' allows the use of an immunoenzymatic assay for their detection.
L'invention concerne des anticorps monoclonaux qui se fixent sur le domaine extracellulaire de l'antigène membranaire spécifique de la prostate (PSMA), des souches cellulaires d'hybridomes produisant lesdits anticorps, ainsi que des méthodes permettant d'utiliser ces anticorps pour le diagnostic et le traitement du cancer. Elle concerne notamment trois anticorps monoclonaux réagissant avec le PSMA exprimé à la surface de la cellule et dans le sérum des patients atteints de cancer de la prostate. Elle concerne également une nouvelle variante protéique (PSM') du PSMA détectée par un anticorps de l'invention. L'activité hydrolase du PSMA et du PSM' permet d'utiliser un dosage immuno-enzymatique pour leur détection.
Boynton Alton L.
Holmes Eric H.
Murphy Gerald P.
Tino William T.
Medarex Inc.
Osler Hoskin & Harcourt Llp
Pacific Northwest Cancer Foundation
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