C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 49/00 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2600912
The invention relates to the use of an expression vector construction coding for the functional HLA-DPal03ß401 complex specifically identified by anti-HLA-DP antibodies, in order to create transgenic mice. The invention also relates to the use of the transgenic mice obtained, such as for the comparative preclinical study of the efficacy of vaccine candidates in order to asses the risks associated with the unwanted induction of an autoimmune disease and in order to determine a therapeutic strategy.
L'invention a pour objet l'utilisation d'une construction de vecteur d'expression, codant pour le complexe HLA-DP.alpha.l03~401 fonctionnel reconnu spécifiquement par des anticorps anti-HLA-DP, pour créer des souris transgéniques. Application des souris transgéniques obtenues, notamment, pour l'étude pré-clinique comparative de l'efficacité de candidats vaccins, pour évaluer les risques liés à une induction non désirée de maladie auto-immune et pour déterminer une stratégie thérapeutique.
Lemonnier Francois
Lone Yu-Chun
Pajot Anthony
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Centre National de La Recherche Scientific (c.n.r.s.)
Institut National de La Sante Et de La Recherche Medicale (inser
Institut Pasteur
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