Aminoalkylamide substituted cyclohexyl derivatives

Details Aminoalkylamide substituted cyclohexyl derivatives Aminoalkylamide substituted cyclohexyl derivatives

C - Chemistry, Metallurgy

07

C

C07C 311/20 (2006.01) A61K 31/18 (2006.01) A61K 31/325 (2006.01) A61P 9/10 (2006.01) C07C 271/24 (2006.01) C07D 239/42 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2539159

The present invention relates to compounds of formula (I); wherein R1, R2, R3, R4, R5, U, V, W, k and m are as defined in the description and claims, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasit infections, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.

L'invention concerne des composés de formule (I); dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, U, V, W, k et m sont tels que définis dans la description et les revendications, et des sels et/ou des esters de ceux-ci acceptables sur le plan pharmaceutique. Les composés sont utiles dans le traitement et/ou la prophylaxie de maladies associées à la 2,3-oxydosqualène-lanostérol cyclase, telle que l'hypercholestérolémie, la hyperlipémie, l'artériosclérose, des maladies vasculaires, des mycoses, des infections parasitaires, des calculs biliaires, des tumeurs et/ou des troubles hyperprolifératifs et dans le traitement et/ou la prophylaxie d'une diminution de la tolérance au glucose et de diabètes.

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