Immunomodulatory therapeutic agents

A - Human Necessities – 61 – K

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A61K 38/36 (2006.01)

Patent

CA 2753871

A group of peptides has been isolated from the serum of domesticated mammals and then identified through the use of mass spectrometry. These peptides are byproducts of fibrinogen activation and the complement cascade. The peptides of greatest activity are the activated forms of fibrinopeptide A and fibrinopeptide B {activated by the removal of the terminal Argi-nine). and an immunomodulatory fragment of Complement Component 3. These form of fibrinopeptides A and B have remarkable immunomodulatory ability, enhancing recognition of foreign substances including infectious agents of all types, decreasing the inflammatory response, preventing the deposition of extravascular fibrin, stimulating the resorption of fibrin that has already been deposited, enhancing the body's ability to recognize and eliminate neoplastic cells, decreasing symptoms of allergic reaction including allergic rhinitis and anaphylaxis, decrease the formation and deposit of autoantibody complexes, ameliorate the symptoms of chronic neurologic disease, and decrease the symptoms of chronic pain syndromes.

Selon l'invention, un groupe de peptides a été isolé à partir du sérum de mammifères domestiqués puis identifié par l'utilisation de la spectrométrie de masse. Ces peptides sont des sous-produits de l'activation du fibrinogène et de la cascade du complément. Les peptides d'activité la plus importante sont les formes activées du fibrinopeptide A et du fibrinopeptide B (activées par l'élimination de l'Arginine terminale) et un fragment immunomodulateur du composant 3 du complément. Ces formes des fibrinopeptides A et B ont une aptitude immunomodulatrice remarquable, améliorant la reconnaissance de substances étrangères comprenant des agents infectieux de tous types, la diminution de la réponse inflammatoire, la prévention du dépôt de fibrine extracellulaire, la stimulation de la résorption de fibrine qui a déjà été déposée, l'amélioration de l'aptitude du corps à reconnaître et à éliminer des cellules néoplasiques, la diminution de symptômes de réaction allergique comprenant une rhinite allergique et une anaphylaxie, la diminution de la formation et du dépôt de complexes auto-anticorps, l'amélioration des symptômes d'une maladie neurologique chronique et la diminution des symptômes de syndromes de douleur chronique.

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