Tumor vaccine

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/00 (2006.01) C12N 5/09 (2010.01) A61K 39/00 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2540283

The invention provides a tumor cell genetically modified to express a nucleic acid encoding CD80 (B7. 1) and a nucleic acid encoding an HLA antigen. The invention also provides a method of stimulating an immune response to a tumor by administering an allogeneic tumor cell such as a lung cancer cell genetically modified to express a nucleic acid encoding CD80 (B7.1) and a nucleic acid encoding an HLA antigen. The invention additionally provides a method of inhibiting a tumor by administering an allogeneic tumor cell such as a lung cancer cell genetically modified to express a nucleic acid encoding CD80 (B7.1) and a nucleic acid encoding an HLA antigen.

L'invention concerne une cellule tumorale génétiquement modifiée pour exprimer un acide nucléique codant CD80 (B7. 1) et un acide nucléique codant un antigène HLA. L'invention concerne également un procédé de stimulation d'une réaction immunitaire contre une tumeur, qui consiste à administrer une cellule tumorale allogénique, telle qu'une cellule cancéreuse du poumon génétiquement modifiée, en vue d'exprimer un acide nucléique codant CD80 (B7. 1) et un acide nucléique codant un antigène HLA. L'invention concerne en outre une méthode d'inhibition d'une tumeur, qui consiste à administrer une cellule tumorale allogénique, telle qu'une cellule cancéreuse du poumon génétiquement modifiée, en vue d'exprimer un acide nucléique codant CD80 (B7. 1) et un acide nucléique codant un antigène HLA.

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