Cinnoline-3-carboxylic acid derivatives

Details Cinnoline-3-carboxylic acid derivatives Cinnoline-3-carboxylic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 451/00 (2006.01) A61K 31/50 (2006.01) C07D 451/04 (2006.01) C07D 451/06 (2006.01) C07D 453/02 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2091375

- 73 - Abstract of Disclosure: A novel cinnoline derivative having an antagonistic activity against serotonin 5-HT3 receptor, its pharmaceutically acceptable salts, its N-oxide derivatives or solvates thereof, and pharmaceutical formulations containing the same for the prevention and/or treatment of various disorders such as nausea and/or emesis caused by anticancer drugs or the X-ray treatment, central nervous disorders such as anxiety and/or neuropathy, gastroenteric diseases such as indigestion, chronic gastritis, digestive ulcer, irritable bowel syndromes and the like, hemicrania, cluster headache, trigeminal neuralgia, arrhythmia and the like.

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