C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/00 (2006.01) A61K 38/04 (2006.01) A61P 9/06 (2006.01)
Patent
CA 2550632
The invention relates to isopeptides capable of modulating intracellular gap junctional communication. The invention further relates to methods of using the isopeptides to maintain or enhance such communication. In one aspect, the isopeptides are antiarrhythmic isopeptides which target the same cells targeted by AAP, AAP10, HP5, and/or functional analogs thereof, i.e. the isopeptides are able to modulate the function of these cells by agonizing or antagonizing the function of AAP, AAP10, HP5, and/or functional analogs thereof.
L'invention concerne des isopeptides capables de moduler la communication par jonction lacunaire intracellulaire. L'invention concerne également des procédés d'utilisation de ces isopeptides pour maintenir ou stimuler cette communication. Dans un premier aspect, ces isopeptides sont des isopeptides anti-arythmisants qui ciblent les mêmes cellules ciblées par AAP, AAP10, HP5, et/ou des analogues fonctionnels de ceux-ci, c.-à-d., les isopeptides sont capables de moduler la fonction de ces cellules par agonisation ou antagonisation de la fonction de AAP, AAP10, HP5, et/ou des analogues fonctionnels de ceux-ci.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Wyeth
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