Composition for lessening oxidative stress

Details Composition for lessening oxidative stress Composition for lessening oxidative stress

A - Human Necessities

61

K

A61K 31/122 (2006.01) A61K 31/085 (2006.01) A61P 39/06 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2461013

The present invention provides an antioxidative composition with high safety, which is capable of lessening oxidative stress due to active oxygen species, free radicals, or the like in vivo, thereby preventing the occurrence or worsening of a disease. It was confirmed that by using a composition containing oxidized coenzyme Q and/or reduced coenzyme Q, the amount of urinary 8-hydroxydeoxyquanosine can be decreased in normal or diabetic animals. Also, in histopathological research of the spleens of diabetic rats, it was confirmed that spleen tissue denaturation caused by oxidative stress can be prevented. It was thus found that oxidative stress in vivo can be lessened. According to the present invention, oxidative stress in vivo can be lessened by using a composition containing coenzyme Q as an active ingredient.

L'invention vise à mettre en oeuvre des compositions permettant de réduire in vivo le stress oxydatif provoqué par de l'oxygène actif, des radicaux libres etc. de manière à empêcher la déclaration ou l'aggravation de maladies, avec un degré de sécurité élevé. L'utilisation de compositions contenant la coenzyme Q de type oxydation et/ou la coenzyme Q de type réduction permet de réduire le taux de 8-hydroxydésoxyguanosine urinaire chez des animaux normaux et diabétiques. Par ailleurs, il a été prouvé de façon histopathologique que la dénaturation tissulaire provoquée par le stress oxydatif peut être éliminée chez des rats diabétiques. Ainsi, le stress oxydatif peut être réduit in vivo au moyen de compositions contenant la coenzyme Q en tant qu'agent actif.

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