Asymmetric process for making substituted 2-amino-thiazolones

Details Asymmetric process for making substituted 2-amino-thiazolones Asymmetric process for making substituted 2-amino-thiazolones

C - Chemistry, Metallurgy

07

D

C07D 277/54 (2006.01) C07D 233/88 (2006.01) C07D 263/48 (2006.01)

Patent

CA 2730711

The invention provides two process for synthesizing substituted aminothiazolone compounds as inhibitors of 11-.beta.--hydroxy steroid dehydrogenase type 1. The processes allow the stereoselective synthesis of the desired compounds without the use of stoichiometric amounts of chiral catalysts.

L'invention fournit deux processus pour synthétiser des composés d'aminothiazolone substitués en tant qu'inhibiteurs de déshydrogénase stéroïde 11-ß-hydroxy de type 1. Les processus permettent la synthèse stéréosélective des composés souhaités sans l'utilisation de quantités stchiométriques de catalyseurs chiraux.

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