C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/10 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C12N 5/02 (2006.01)
Patent
CA 2716343
The present invention relates to the identification of microRNAs that regulate smooth muscle cell proliferation and differentiation, including the miR-143/miR-145 cluster. Methods of treating restenosis and neointima formation by increasing expression of miR-143 and/or miR-145 are disclosed. The present invention also relates to the identification of two microRNAs, miR-486 and miR-422a, that regulate cell survival in the heart. Methods of treating or preventing cardiac hypertrophy, heart failure, or myocardial infarction by increasing expression of miR-486 and/or miR-422a in heart tissue are also disclosed.
La présente invention concerne l'identification de micro-ARN qui régulent la prolifération et la différentiation des cellules des muscles lisses, notamment l'ensemble miR-143/miR-145. L'invention concerne également des procédés de traitement de la resténose et de la formation néo-intime en augmentant l'expression de miR-143 et/ou de miR-145. La présente invention concerne également l'identification de deux micro-ARN, à savoir miR-486 et miR-422a, qui régulent la survie des cellules dans le coeur. L'invention concerne également des procédés de traitement ou de prévention de l'hypertrophie cardiaque, des crises cardiaques ou de l'infarctus du myocarde en augmentant l'expression de miR-486 et/ou de miR-422a dans le tissu cardiaque.
Olson Eric
Small Eric
Xin Mei
Deeth Williams Wall Llp
The Board Of Regents Of The University Of Texas System
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