Modulators of cytokine mediated signalling pathways and...

A - Human Necessities – 61 – K

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A61K 45/06 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2386230

The invention relates to the use of modulators of cytokine mediated signalling pathways in combination with integrin .alpha.v.beta.3, receptor antagonists for the treatment or prevention of diseases, particularly to the use of pharmaceutical composition, compris-ing a modulator of cytokine mediated signalling pathways and an integrin .alpha.v.beta.3 receptor antagonist, for the treatment or prevention of inflammatory or autoimmune disorders, particularly for the treatment or prevention of rheumatoid arthritis and to the pharmaceutical composition itself.

L'invention concerne l'utilisation de modulateurs de voies de signalisation associées à la cytokine en combinaison avec des antagonistes du récepteur alpha v beta 3 d'intégrine pour le traitement ou la prévention de maladies. En particulier, l'invention concerne l'utilisation d'une composition pharmaceutique comprenant un modulateur de voies de signalisation associées à la cytokine, et un antagoniste du récepteur alpha v beta 3 d'intégrine, pour le traitement ou la prévention de troubles inflammatoires ou auto-immuns, en particulier pour le traitement ou la prévention de la polyarthrite rhumatoïde. L'invention concerne également la composition pharmaceutique elle-même.

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