Methods to prevent tumor recurrence by blockade of tgf-.beta.

Details Methods to prevent tumor recurrence by blockade of tgf-.beta. Methods to prevent tumor recurrence by blockade of tgf-.beta.

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 39/395 (2006.01) C07K 16/22 (2006.01)

Patent

CA 2502663

Methods are provided herein to prevent a tumor recurrence in a subject, involving administering to the subject an agent that blocks the TGF-.beta. signaling pathway. In one embodiment, the agent inhibits the immunosuppressive effects of TGF-.beta.. Also provided is a method of enhancing an immune respond in a subject to inhibit recurrence of a tumor by administering an agent which blocks the TGF-.beta. signaling pathway. A method of enhancing the activity of an immune cell to inhibit recurrence of a tumor by contacting a TGF-.beta. receptor-expressing cell with an agent which blocks the TGF-.beta. signaling pathway is also provided, as are methods of screening for an agent that inhibits or measurably reduces the recurrence of a tumor.

L'invention concerne des méthodes pouvant empêcher la récurrence d'une tumeur chez un sujet. La méthode consiste à administrer au sujet un agent qui bloque la voie de signalisation du TGF-B. Dans un mode de réalisation, l'agent inhibe les effets immunosuppresseurs du TGF-B. L'invention concerne également une méthode de renforcement de la réponse immunitaire chez un sujet, pour inhiber la récurrence d'une tumeur, par administration d'un agent qui bloque la voie de signalisation du TGF-B. Elle concerne une méthode de renforcement de l'activité d'une cellule immunitaire pour inhiber la récurrence d'une tumeur, qui consiste à placer une cellule exprimant le récepteur du TGF-? au contact d'un agent qui bloque la voie de signalisation du TGF-B. L'invention concerne en outre des méthodes de criblage destinées à identifier un agent qui inhibe ou réduit de façon mesurable la récurrence d'une tumeur.

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