C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/47 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2416785
The invention relates to novel aryl-ethene sulfonamides of the general formula (I); wherein the symbols R1-R6, X, Y, Z and Q have the significance given in the description; and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists.
L'invention concerne de nouveaux sulfonamides aryléthène et leur utilisation comme ingrédients actifs dans la préparation de compositions pharmaceutiques. L'invention concerne également des aspects associés comprenant des procédés de préparation de ces composants, des compositions pharmaceutiques contenant un ou plusieurs de ce(s) composants et en particulier, leur utilisation comme antagonistes de récepteur de l'endothéline.
Bolli Martin
Boss Christoph
Clozel Martine
Fischli Walter
Weller Thomas
Actelion Pharmaceuticals Ltd
Gowling Lafleur Henderson Llp
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