Cyclic nucleotide phosphodiesterase inhibitors, preparation...

Details Cyclic nucleotide phosphodiesterase inhibitors, preparation... Cyclic nucleotide phosphodiesterase inhibitors, preparation...

A - Human Necessities

61

K

A61K 31/5513 (2006.01) A61K 31/5517 (2006.01) A61P 3/04 (2006.01) A61P 11/06 (2006.01) A61P 19/02 (2006.01) A61P 21/00 (2006.01) A61P 25/08 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/20 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 25/30 (2006.01) A61P 37/00 (2006.01) C07D 243/20 (2006.01) C07D 243/22 (2006.01) C07D 243/24 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 417/10 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2503716

The invention concerns the use of PDE2 inhibitors for treating disorders of the central and peripheral nervous system, a method for therapeutic treatment by administering to an animal said inhibitors. More specifically, the invention concerns novel benzodiazepinone derivatives and their uses in therapeutics more particularly for treating pathologies involving activity of type 2 cyclic nucleotide phosphodiesterase. The invention also concerns methods for preparing same and novel synthesis intermediates.

L'invention concerne l'utilisation d'inhibiteurs de PDE2 pour traiter des désordres du système nerveux central et périphérique, un procédé de traitement thérapeutique par administration chez un animal de ces inhibiteurs. Elle concerne plus spécifiquement de nouveaux dérivés de type benzodiazépinones et leurs applications dans le domaine thérapeutique tout particulièrement pour le traitement de pathologies impliquant l'activité d'une phosphodiestérase de nucléotides cycliques de type 2. Elle concerne également des procédés pour leur préparation et de nouveaux intermédiaires de synthèse.

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