Triazole-substituted arylamide derivatives and their use as...

Details Triazole-substituted arylamide derivatives and their use as... Triazole-substituted arylamide derivatives and their use as...

C - Chemistry, Metallurgy

07

D

C07D 249/06 (2006.01) A61K 31/4192 (2006.01) A61K 31/497 (2006.01) A61P 11/00 (2006.01) A61P 13/02 (2006.01) A61P 29/00 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2707422

Compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted triazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

L'invention concerne des composés de formule (I), ou un sel de ceux-ci pharmaceutiquement acceptable, dans laquelle R1 est éventuellement triazolyl substitué, et R2, R3, R4, R5, R6, R7 et R8 sont tels que définis dans le descriptif. L'invention concerne également des procédés d'utilisation de ces composés pour le traitement de maladies associées aux antagonistes du récepteur P2X3 et/ou P2X2/3, ainsi que des procédés de fabrication de ces composés.

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