Rnai therapeutic for respiratory virus infection

Details Rnai therapeutic for respiratory virus infection Rnai therapeutic for respiratory virus infection

C - Chemistry, Metallurgy

12

N

C12N 15/45 (2006.01) A61K 9/00 (2006.01) A61K 31/7105 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 31/12 (2006.01) C07H 21/02 (2006.01) C12N 15/33 (2006.01) C12N 15/41 (2006.01) C12N 15/44 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2603842

Disclosed herein is a double stranded siRNA molecule that inhibits production of a respiratory virus, wherein each strand of said siRNA molecule is about 15 to about 50 nucleotides, and wherein one strand of said siRNA molecule comprises a nucleic acid sequence identical to a conserved site, or a variant thereof, within the nucleic acid sequence of the respiratory virus, and uses thereof.

L'invention concerne une molécule d'ARNsi à double brin inhibant la production d'un virus respiratoire, chaque brin de la molécule d'ARNsi comprend entre environ 15 et environ 50 nucléotides et un brin de la molécule d'ARNsi comprend une séquence d'acide nucléique identique au site conservé, ou une variante, dans la séquence d'acide nucléique du virus respiratoire. L'invention concerne également les utilisations associées.

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