C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/14 (2006.01) A61K 31/4985 (2006.01) A61P 9/00 (2006.01) A61P 15/10 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 241/00 (2006.01)
Patent
CA 2445625
Compounds of the general structural formula (I), and use of the compounds and salts and solvates thereof, as thereapeutic agents. In particular, the invention relates to compounds that are potent and selective inhibitors of cyclic guanosine 3', 5'-monophosphate specific phosphodiesterase (cGMP- specific PDE), in particular PDE5, and have utility in a variety of therapeutic areas wherein such inhibition is considered beneficial, including the treatment of cardiovascular disorders and erectile dysfunction.
La présente invention, qui concerne des composés présentant la structure générale (I), concerne également l'utilisation de ces composés, de leurs sels et de leurs solvates comme agents thérapeutiques. L'invention concerne plus particulièrement des composés inhibiteurs puissants et sélectifs de la phosphodiestérase spécifique du 3',5'-monophosphate cyclique de la guanosine (PDE spécifique cGMP), et notamment le PDE5. Ces derniers composés conviennent dans de nombreux domaines thérapeutiques où une telle inhibition constitue un avantage, et notamment pour le traitement de troubles cardio-vasculaires et de la dysérection.
Orme Mark W.
Sawyer Jason Scott
Schultze Lisa M.
Lilly Icos Llc
Ridout & Maybee Llp
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