C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2613068
The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: Formula (I) where R1 , R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK.beta.) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
L'invention concerne de nouveaux dérivés d'indole carboxamide. Plus particulièrement, l'invention concerne des composés de formule (I) dans laquelle R1, R2, R3, U et V sont définis ci-après et leurs sels pharmaceutiquement acceptables. Les composés de l'invention sont des inhibiteurs d'IKK2 et peuvent être utiles dans le traitement de troubles associés à une activité IKK2 appropriée (également connue comme IKK.beta.), telle que la polyarthrite rhumatoïde, l'asthme et la MPOC (maladie pulmonaire obstructive chronique). En conséquence, l'invention concerne également des compositions pharmaceutiques renfermant un composant de l'invention. L'invention concerne également des méthodes d'inhibition de l'activité IKK2 et de traitement de troubles associés utilisant un composé de l'invention ou une composition pharmaceutique renfermant un composé de l'invention.
Deng Jianghe
Jin Qi
Kerns Jeffrey K.
Lin Guoliang
Lin Xichen
Glaxosmithkline Llc
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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