Use of succinic acid or salts thereof for the treatment of...

Details Use of succinic acid or salts thereof for the treatment of... Use of succinic acid or salts thereof for the treatment of...

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61K 31/194 (2006.01) A61K 31/38 (2006.01)

Patent

CA 2362116

The invention relates to the use of succinic acid or pharmaceutically acceptable salts thereof for manufacture of medicaments or nutritional supplements effective for treating disease states caused by dysfunctional signal transdunction, preferably diabetes mellitus, and for treating wounds. The invention provides methods of inhibiting protein tyrosine phosphatase activity and of treating disease states caused by dysfunctional signal transduction, which comprises administering succinic acid or a pharmaceutically acceptable salts thereof alone or in combination with activators of protein tyrosine kinases, preferably with insulin.

Cette invention concerne l'utilisation d'acide succinique, ou de sels d'acide succinique pharmaceutiquement acceptables, dans la fabrication de médicaments ou d'additifs nutritionnels efficaces qui permettent de traiter des états maladifs induits par un dysfonctionnement de la transduction de signaux, de préférence le diabète, et qui permettent de cicatriser des blessures. Cette invention concerne plus précisément des procédés qui permettent d'inhiber l'activité de la protéine tyrosine phosphatase, et de traiter des états maladifs induits par un dysfonctionnement de la transduction de signaux. Ces procédés consistent à administrer de l'acide succinique, ou des sels pharmaceutiquement acceptable de celui-ci, soit seul, soit en combinaison avec des activateurs de protéine tyrosine kinases, de préférence avec de l'insuline.

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