Triazolopyrimidinol compounds and salts thereof

Details Triazolopyrimidinol compounds and salts thereof Triazolopyrimidinol compounds and salts thereof

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61P 9/00 (2006.01) C07D 239/00 (2006.01) C07D 249/00 (2006.01)

Patent

CA 2367899

Isolated 7-[1-(4-chlorophenoxy)ethyl]-1,2,4-triazolo[1,5-a]pyrimidin-5-ol and pharmaceutically acceptable salts thereof in the form of individual enantiomers and mixtures thereof including the racemic mixture, pharmaceutical formulations containing this compound and the use of this compound in the treatment of seizures, neurological disorders such as epilepsy and/or conditions in which there is neurological damage such as stroke, brain trauma, head injuries and haemorrhage, are described.

L'invention concerne du 7-[1-(4-chlorophenoxy)éthyl]-1,2,4-triazolo[1,5-a]pyrimidin-5-ol isolé ainsi que ses sels pharmaceutiquement acceptables sous forme d'énantiomères individuels et leurs mélanges, y compris le mélange racémique. L'invention concerne également des formulations pharmaceutiques contenant ce composé et l'utilisation de ce composé dans le traitement de crises, de troubles neurologiques tels que l'épilepsie et/ou de lésions liées à une altération neurologique telle que les crises d'apoplexie, les lésions cérébrales, les traumatismes crâniens et les hémorragies cérébrales.

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