Vaccine compositions for mucosal administration comprising...

Details Vaccine compositions for mucosal administration comprising... Vaccine compositions for mucosal administration comprising...

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 39/145 (2006.01)

Patent

CA 2310718

The invention provides a vaccine composition adapted for mucosal administration; the composition comprising one or more influenza vaccine antigens and an effective adjuvant amount of an acid addition salt of a chitosan wherein the chitosan is a deacetylated chitin which is at least 80 % deacetylated and has a weight average molecular weight of between 10,000 and 100,000.

L'invention concerne une composition vaccinale destinée à être administrée dans les muqueuses. Cette composition renferme un ou plusieurs antigènes de vaccin contre la grippe, ainsi qu'une quantité efficace d'un adjuvant d'un sel d'addition acide d'un chitosane. Ce chitosane se présente sous la forme d'une chitine, laquelle est désacétylée à hauteur d'au moins 80 % et présente une masse moléculaire moyenne en poids variant entre 10 000 et 100 000.

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