Materials and methods relating to the diagnosis and...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) C07K 16/18 (2006.01) C12Q 1/32 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2264939

The present invention relates to materials and methods for the diagnosis and treatment of pre-eclampsia, and more particularly to the role of P-type inositolphosphoglycans (IPGs) in the occurrence of pre-eclampsia. Methods of diagnosing pre-eclampsia by determining the level of P-type IPGs and uses of antagonists of P-type IPGs in the treatment of pre-eclampsia are disclosed, together with a method for screening for P-type IPG antagonists.

L'invention se rapporte à des substances et à des méthodes destinées au diagnostic et au traitement de la prééclampsie et du diabète; elle concerne notamment le rôle des phosphoglycans d'inositol du type P (des IPG) dans l'apparition de la prééclampsie. L'invention a pour objet des méthodes de diagnostic de la prééclampsie qui permettent de déterminer le niveau des IPG du type P et d'utiliser les antagonistes des IPG du type P pour traiter la prééclampsie, ainsi qu'une méthode de criblage des antagonistes des IPG du type P.

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