Modulation of telomere length in telomerase positive cells...

Details Modulation of telomere length in telomerase positive cells... Modulation of telomere length in telomerase positive cells...

A - Human Necessities

61

K

A61K 31/522 (2006.01) A61K 31/7072 (2006.01) A61K 31/708 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2602562

Induction of telomere shortening, G2 arrest and apoptosis in telomerase positive cancer cells using acyclic nucleoside analogs has been disclosed. In addition, methods for impairment or prevention of tumorigenic telomerase positive cells from having a chance to grow into a tumor and methods for promoting tumor regression (decrease in size of an established tumor) using acyclic nucleoside analogs has been disclosed.

L'invention concerne l'induction d'un raccourcissement des télomères, d'un arrêt de la phase G2 et d'une apoptose dans des cellules cancéreuses télomérase positives à l'aide d'analogues de nucléosides acyliques. En outre, l'invention concerne des méthodes destinées à altérer ou à empêcher la possibilité pour des cellules tumorigènes télomérase positives de présenter une chance de se développer dans une tumeur ainsi que des méthodes destinées à favoriser une régression tumorale (diminution de taille d'une tumeur établie) à l'aide d'analogues de nucléosides acyliques.

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