Hiv protease inhibitors useful for the treatment of aids

Details Hiv protease inhibitors useful for the treatment of aids Hiv protease inhibitors useful for the treatment of aids

C - Chemistry, Metallurgy

07

D

C07D 307/20 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) C07D 309/10 (2006.01) C07D 309/12 (2006.01) C07D 333/32 (2006.01) C07D 333/48 (2006.01) C07D 335/02 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 453/02 (2006.01)

Patent

CA 2075666

95/RDM55 98/RDM56 18414 TITLE OF THE, INVENTION HIV PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF AIDS ABSTRACT OF THE DISCLOSURE Compounds of the form, A-G-J wherein A is an amine protecting group or urethane, G a dipeptide isostere and J a small terminal group are described. They are distinguished by tetrahydrofuryl or tetrahydropyranyl substituents, and the like. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically 95/RDM55 98/RDM56 - ii - 414 acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

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