Amino-substituted heterocycles as renin inhibitors

Details Amino-substituted heterocycles as renin inhibitors Amino-substituted heterocycles as renin inhibitors

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 38/04 (2006.01) C07D 233/88 (2006.01) C07D 277/40 (2006.01) C07K 5/02 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2017552

ABSTRACT OF THE DISCLOSURE The invention concerns novel renin-inhibitory compounds which contain an amino-substituted heterocycle at the P2 position. These are useful for treating renin-associated hypertension, congestive heart failure, glaucoma, hyperaldosteronism, and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the compounds, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, or hyperaldosteronism.

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