A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) C07K 16/40 (2006.01) C12N 9/00 (2006.01)
Patent
CA 2476938
Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15 or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer (neoplastic) or pre- cancerous (pre-neoplastic) cells are provided. Methods for the prevention or treatment of cancer via administration of these compositions are also provided.
L'invention concerne des compositions et des méthodes d'utilisation de compositions induisant UBE1L ou une protéine ISG15 de type ubiquitine ou inhibant une déconjugase UBP43 afin de dégrader des protéines oncogènes et une apoptose de cancer (néoplasique) ou de cellules précancéreuses (pré-néoplasique). L'invention concerne également des méthodes permettant de prévenir et de traiter un cancer par administration de ces compositions.
Dmitrovsky Ethan
Hassel Bret A.
Kitareewan Sutisak
Pitha-Rowe Ian
Borden Ladner Gervais Llp
Trustees Of Dartmouth College
University Of Maryland Baltimore
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