Method and device for synovial cell-charged collagen...

A - Human Necessities – 61 – L

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Details

A61L 27/36 (2006.01) A61F 2/30 (2006.01) A61L 27/38 (2006.01)

Patent

CA 2627121

An implant for repair of a cartilaginous defect in a subject includes a collagen matrix charged with synovial cells. A method preparing an implant for repair of a cartilaginous defect in a subject includes obtaining a fluid containing synovial cells and charging the synovial cells to the matrix. A device for preparing a cell-charged implant includes a first chamber and a second chamber, the first and second chambers being separated by a membrane and a perforated filter. The membrane is adapted to collect cells from a cell- containing fluid introduced into the first chamber and the perforated filter is adapted to permit passage or diffusion of the fluid through the second chamber. A method for preparing a cell-charged implant utilizes the device.

La présente invention concerne un implant permettant de réparer chez un patient un défaut du cartilage. Cet implant comprend une matrice de collagène chargée de cellules synoviales. L'invention concerne également un procédé permettant d'élaborer un implant destiné à réparer chez un patient un défaut du cartilage. Ce procédé consiste à prélever un fluide contenant des cellules synoviales et à charger de cellules synoviales la matrice. L'invention concerne aussi un dispositif permettant d'élaborer l'implant chargé de cellules. Ce dispositif comporte deux chambres séparées par une membrane et un filtre perforé. La membrane est conçue pour recueillir des cellules provenant d'un fluide contenant ces cellules et introduit dans la première chambre, le filtre perforé étant conçu pour laisser passer ou diffuser le fluide par la deuxième chambre. L'invention concerne enfin un procédé d'élaboration d'un implant chargé de cellules et utilisant ce dispositif.

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