C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 317/14 (2006.01) A61K 31/185 (2006.01) A61K 31/435 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 37/00 (2006.01) C07C 317/22 (2006.01) C07C 317/36 (2006.01) C07D 213/71 (2006.01) C07D 295/26 (2006.01)
Patent
CA 2740863
The invention is concerned with the compounds of formula I, and pharmaceutically acceptable salts and esters thereof, wherein W, X, Y, and R1- R7 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
La présente invention concerne les composés de formule I, ainsi que leurs sels et esters de qualité pharmaceutique, où W, X, Y et R1-R7 sont tels que définis dans la description détaillée et dans les revendications. De plus, la présente invention concerne des méthodes de fabrication et d'emploi des composés de formule I ainsi que des compositions pharmaceutiques contenant de tels composés. Les composés de formule I sont des antagonistes ou des agonistes partiels du récepteur CRTH2 et peuvent être employés dans le traitement de pathologies et de troubles associés à ce récepteur, comme l'asthme.
Chen Li
Firooznia Fariborz
Gillespie Paul
He Yun
Lin Tai-An
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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