C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) G01N 33/68 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2325864
The invention concerns a method for identifying peptide compounds derived from hsp70, having at least one mutation relative to the hsp70 natural sequence, said compounds bringing about a response T specific of tumours, and the peptide compounds obtainable by said method. The invention also concerns the use of said peptide compounds for performing repeated immunisation in a subject so as to interrupt immune tolerance for the corresponding natural (non-mutated) peptide. Said peptide compounds are useful for preparing a medicine designed in particular for treating cancer optionally in combination with any agent provoking tumour cell stress.
La présente invention concerne un procédé d'identification de composés peptidiques dérivés d'hsp70, qui présentent au moins une mutation par rapport à la séquence naturelle d'hsp70, lesdits composés entraînant une réponse T spécifique des tumeurs, ainsi que les composés peptidiques susceptibles d'être obtenus par ledit procédé. L'invention porte également sur l'utilisation desdits composés peptidiques pour effectuer une immunisation répétée chez un individu de sorte à rompre la tolérance immunitaire pour le peptide naturel (non muté) correspondant. Les composés peptidiques sont utiles pour la fabrication d'un médicament destiné en particulier au traitement du cancer éventuellement en association avec tout agent provoquant un stress des cellules tumorales.
Gaudin Catherine
Triebel Frederic
Institut Gustave-Roussy
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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