C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 279/06 (2006.01) A61K 31/54 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2153690
The present invention relates to novel substituted thiosemicarbazonic acid esters of formula (I) wherein R1 is lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, or aryl-lower alkyl, R2 is hydrogen, lower alkyl, aryl, aryl- lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, unsaturated or saturated heterocyclyl-lower alkyl, lower alkoxycarbonyl-lower alkyl or the group -C(=O)-R3, wherein R3 is lower alkyl, aryl, aryl-lower alkyl, aryl-lower alcenyl, heteroaryl (hetaryl), aryloxy, aryl-lower alkoxy or lower alk-2-en-1- yloxy, and R4 is lower alkyl, lower alkoxy, lower alk-2-en-1-yl, lower alk-2- yn-1-yl, aryl-lower alkyl, aryl-lower alkenyl, or also lower alkoxycarbonyl- lower alkyl, and the salts thereof, to a process for the preparation of said compounds, to pharmaceutical compositions containing them, and to the use thereof as medicaments.
La présente invention se rapporte à des nouveaux esters de l'acide thiosemicarbazonique substitué de la formule (I) dans laquelle R¿1? est alkyle inférieur, alc-2-én-1-yle inférieur, alc-2-yn-1-yle inférieur, ou aryle-alkyle inférieur, R¿2? est hydrogène, alkyle inférieur, aryle, aryle-alkyle inférieur, alc-2-én-1-yle inférieur, alc-2-yn-1-yle inférieur, hétérocyclyle-alkyle inférieur saturé ou insaturé, alcoxycarbonyle inférieur-alkyle inférieur ou le groupe -C(=O)-R¿3? dans lequel R¿3? est alkyle inférieur, aryle, aryle-alkyle inférieur, aryle-alcényle inférieur, hétéroaryle (hétaryle), aryloxy, aryle-alcoxy inférieur ou alc-2-én-1-yloxy inférieur, et R¿4? est alkyle inférieur, alcoxy inférieur, alc-2-én-1-yle inférieur, alc-2-yn-1-yle inférieur, aryle-alkyle inférieur, aryle-alcényle inférieur, ou également alcoxycarbonyle inférieur-alkyle inférieur. L'invention concerne également les sels de ces composés, un procédé de préparation de ces composés, des compositions pharmaceutiques contenant ceux-ci, et l'utilisation de ces composés en tant que médicaments.
Ag Ciba-Geigy
Fetherstonhaugh & Co.
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