Immunogenic compositions containing antigens, gene vectors...

Details Immunogenic compositions containing antigens, gene vectors... Immunogenic compositions containing antigens, gene vectors...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 9/113 (2006.01) A61K 9/16 (2006.01) A61K 31/7088 (2006.01) A61K 39/04 (2006.01) A61K 39/39 (2006.01) A61K 47/30 (2006.01) A61P 31/06 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2453959

The present invention relates to compositions which are able to stimulate an immune response in a host inoculated with an antigen of interest or the gene vector that codifies it. This composition includes microspheres based on copolymers derived from lactic acid glycolic acid encapsulating antigens, gene vectors and/or adjuvants with immunostimulatory properties obtained from mycobacterial fractions. The materialization of the present invention is the use of trehalose dimycolate associated to a heat shock protein or to the plasmid containing the gene that codifies it, encapsulated in microspheres with size smaller than 10 µm, capable of inducing specific antobodies and cellular immune responses, as well as the secretion of cytokines implicated in the protection against infectious diseases and cancer, following administration of a single dose or several doses.

L'invention concerne des compositions capables de stimuler une réponse immune chez un hôte auquel on a inoculé un antigène d'intérêt ou le vecteur génique qui le codifie. Cette composition comporte des microsphères à base de copolymères dérivés d'acide lactique et d'acide glycolique enrobant des antigènes, des vecteurs géniques et/ou des adjuvants présentant des propriétés immunostimulatrices obtenues à partir de fractions mycobactériennes. L'invention se caractérise en ce que l'on utilise du tréhalose dimycolate associé à une protéine de choc thermique ou au plasmide renfermant le gène le codifiant, enrobé dans des microsphères dont les dimensions n'excèdent pas 10 µm, capable d'induire des anticorps spécifiques et des réponses immunes cellulaires, ainsi que la sécrétion de cytokines impliquées dans la protection contre des maladies infectieuses et cancers, après administration d'une ou de plusieurs doses.

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