Process for preparing and drying solid rasagiline base

Details Process for preparing and drying solid rasagiline base Process for preparing and drying solid rasagiline base

C - Chemistry, Metallurgy

07

C

C07C 211/42 (2006.01) A61K 31/135 (2006.01) C07C 211/38 (2006.01)

Patent

CA 2727017

Disclosed is crystalline R( + ) -N-propargyl-1-aminoindan containing water at an amount of less than 0.5% by weight and a pharmaceutical composition comprising the same, and the process for the manufacture and the validation thereof. Also disclosed is a process for the preparation of solid rasagiline base.

L'invention concerne du R(+)-N-propargyl-1-aminoindane cristallin contenant une quantité d'eau inférieure à 0,5% en poids, une composition pharmaceutique comprenant ces composés et le procédé de fabrication et de validation de celle-ci. L'invention concerne aussi un processus de préparation de rasagiline base solide.

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